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Target
Plasmepsin IV, putative
Ligand
BDBM50298998
Substrate
n/a
Meas. Tech.
ChEMBL_588259 (CHEMBL1050916)
Ki
340±n/a nM
Citation
 Orrling, KM; Marzahn, MR; Gutiérrez-de-Terán, H; Aqvist, J; Dunn, BM; Larhed, M alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem 17:5933-49 (2009) [PubMed]  Article 
Target
Name:
Plasmepsin IV, putative
Synonyms:
Aspartic protease PM4
Type:
PROTEIN
Mol. Mass.:
51656.81
Organism:
Plasmodium vivax
Description:
ChEMBL_588259
Residue:
450
Sequence:
MDIAVKEQDYSNGLIKNSAAFENLKFSNIKNFKVQKRFQILYYILFVFVTGIFFFFLISTYFFTPNYKVNKIVQNTEHLTLAFKIERPYDKVLKTISKKNLKNYIKETFNFFKSGYMKQNYLGSENDVIELDDVANIMFYGEGEVGDNHQKFMLIFDTGSANLWVPSKKCNSSGCSIKNLYDSSKSKSYEKDGTKVDITYGSGTVKGFFSKDLVTLGHLSMPYKFIEVTDTDDLEPIYSSVEFDGILGLGWKDLSIGSIDPIVVELKNQNKIDNALFTFYLPVHDVHAGYLTIGGIEEKFYEGNITYEKLNHDLYWQIDLDVHFGKQTMEKANVIVDSGTTTITAPSEFLNKFFANLNVIKVPFLPFYVTTCDNKEMPTLEFKSANNTYTLEPEYYMNPILEVDDTLCMITMLPVDIDSNTFILGDPFMRKYFTVFDYDKESVGFAIAKN
  
Inhibitor
Name:
BDBM50298998
Synonyms:
(S)-3-((R)-2-((2-(2,6-dimethylphenoxy)acetamido)methyl)-2-hydroxy-4-phenylbutanoyl)-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-5,5-dimethylthiazolidine-4-carboxamide | CHEMBL584190
Type:
Small organic molecule
Emp. Form.:
C36H43N3O6S
Mol. Mass.:
645.808
SMILES:
Cc1cccc(C)c1OCC(=O)NC[C@](O)(CCc1ccccc1)C(=O)N1CSC(C)(C)[C@@H]1C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
Structure:
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