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Target
Potassium voltage-gated channel subfamily A member 1
Ligand
BDBM50299980
Substrate
n/a
Meas. Tech.
ChEMBL_593060 (CHEMBL1039576)
IC50
2660±n/a nM
Citation
 Blass, BE; Fensome, A; Trybulski, E; Magolda, R; Gardell, SJ; Liu, K; Samuel, M; Feingold, I; Huselton, C; Jackson, CM; Djandjighian, L; Ho, D; Hennan, J; Janusz, JM Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem 52:6531-4 (2009) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 1
Synonyms:
KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56451.30
Organism:
Homo sapiens (Human)
Description:
Potassium (voltage dependent) 0 0::Q09470
Residue:
495
Sequence:
MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV
  
Inhibitor
Name:
BDBM50299980
Synonyms:
(R)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxy-phenyl)-2-imidazolidinone | CHEMBL569185
Type:
Small organic molecule
Emp. Form.:
C20H25N3O5S
Mol. Mass.:
419.495
SMILES:
COc1ccc(CCN2[C@@H](CN(NS(C)(=O)=O)C2=O)c2ccc(OC)cc2)cc1 |r|
Structure:
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