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Target
Macrophage metalloelastase
Ligand
BDBM50300465
Substrate
n/a
Meas. Tech.
ChEMBL_592283 (CHEMBL1045857)
IC50
790±n/a nM
Citation
 Holmes, IP; Gaines, S; Watson, SP; Lorthioir, O; Walker, A; Baddeley, SJ; Herbert, S; Egan, D; Convery, MA; Singh, OM; Gross, JW; Strelow, JM; Smith, RH; Amour, AJ; Brown, D; Martin, SL The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett 19:5760-3 (2009) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50300465
Synonyms:
(+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid | 5-(biphenyl-4-yl)-3-hydroxypentanoic acid | CHEMBL572982
Type:
Small organic molecule
Emp. Form.:
C17H18O3
Mol. Mass.:
270.323
SMILES:
OC(CCc1ccc(cc1)-c1ccccc1)CC(O)=O
Structure:
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