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Target
Nuclear factor NF-kappa-B p105 subunit
Ligand
BDBM50300850
Substrate
n/a
Meas. Tech.
ChEMBL_598993 (CHEMBL1041917)
IC50
110000±n/a nM
Citation
 Kobayashi, T; Yoshimori, A; Kino, K; Komori, R; Miyazawa, H; Tanuma, SI A new small molecule that directly inhibits the DNA binding of NF-kappaB. Bioorg Med Chem 17:5293-7 (2009) [PubMed]  Article 
Target
Name:
Nuclear factor NF-kappa-B p105 subunit
Synonyms:
NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit
Type:
Protein
Mol. Mass.:
105329.57
Organism:
Homo sapiens (Human)
Description:
P19838
Residue:
968
Sequence:
MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI
  
Inhibitor
Name:
BDBM50300850
Synonyms:
4,6-dichloro-N-(4-chlorophenyl)-1,3,5-triazin-2-amine | CHEMBL577302
Type:
Small organic molecule
Emp. Form.:
C9H5Cl3N4
Mol. Mass.:
275.522
SMILES:
Clc1ccc(Nc2nc(Cl)nc(Cl)n2)cc1
Structure:
Search PDB for entries with ligand similarity: