Reaction Details Report a problem with these data
Target
Stearoyl-CoA desaturase
Ligand
BDBM50301059
Substrate
n/a
Meas. Tech.
ChEMBL_598345 (CHEMBL1050577)
IC50
68000±n/a nM
Citation
 Li, CS; Belair, L; Guay, J; Murgasva, R; Sturkenboom, W; Ramtohul, YK; Zhang, L; Huang, Z Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett 19:5214-7 (2009) [PubMed]  Article 
Target
Name:
Stearoyl-CoA desaturase
Synonyms:
Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1
Type:
Enzyme
Mol. Mass.:
41537.27
Organism:
Homo sapiens (Human)
Description:
O00767
Residue:
359
Sequence:
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
  
Inhibitor
Name:
BDBM50301059
Synonyms:
2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid | CHEMBL569610
Type:
Small organic molecule
Emp. Form.:
C16H14F3N3O3S
Mol. Mass.:
385.361
SMILES:
OC(=O)c1cnc(s1)N1CCN(CC1)C(=O)c1ccccc1C(F)(F)F
Structure:
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