Reaction Details Report a problem with these data
Target
Acyl-CoA desaturase 1
Ligand
BDBM50301057
Substrate
n/a
Meas. Tech.
ChEMBL_598344 (CHEMBL1041718)
IC50
100±n/a nM
Citation
 Li, CS; Belair, L; Guay, J; Murgasva, R; Sturkenboom, W; Ramtohul, YK; Zhang, L; Huang, Z Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett 19:5214-7 (2009) [PubMed]  Article 
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1)
Type:
Enzyme
Mol. Mass.:
41485.97
Organism:
Rattus norvegicus (Rat)
Description:
P07308
Residue:
358
Sequence:
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50301057
Synonyms:
2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide | CHEMBL576820 | MF-152
Type:
Small organic molecule
Emp. Form.:
C16H15F3N4O2S
Mol. Mass.:
384.376
SMILES:
NC(=O)c1cnc(s1)N1CCN(CC1)C(=O)c1ccccc1C(F)(F)F
Structure:
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