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Target
Transporter
Ligand
BDBM50264063
Substrate
n/a
Meas. Tech.
ChEMBL_598777 (CHEMBL1042017)
Ki
58.2±n/a nM
Citation
 Jobson, NK; Crawford, AR; Dewar, D; Pimlott, SL; Sutherland, A Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett 19:4996-8 (2009) [PubMed]  Article 
Target
Name:
Transporter
Synonyms:
NE transporter | NET | Norepinephrine transporter(NET)
Type:
Multi-pass membrane protein
Mol. Mass.:
69236.90
Organism:
Rattus norvegicus (rat)
Description:
Q63380
Residue:
617
Sequence:
MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWGKEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
  
Inhibitor
Name:
BDBM50264063
Synonyms:
(2R,3S)-iodoreboxetine | (R)-2-((S)-(2-ethoxyphenoxy)(4-iodophenyl)methyl)morpholine | CHEMBL490995
Type:
Small organic molecule
Emp. Form.:
C19H22INO3
Mol. Mass.:
439.2874
SMILES:
CCOc1ccccc1O[C@H]([C@H]1CNCCO1)c1ccc(I)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: