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Target
Cannabinoid receptor 1
Ligand
BDBM50301311
Substrate
n/a
Meas. Tech.
ChEMBL_599307 (CHEMBL1041035)
Ki
>5000±n/a nM
Citation
 Worm, K; Weaver, DG; Green, RC; Saeui, CT; Dulay, DM; Barker, WM; Cassel, JA; Stabley, GJ; DeHaven, RN; LaBuda, CJ; Koblish, M; Brogdon, BL; Smith, SA; Dolle, RE Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists. Bioorg Med Chem Lett 19:5004-8 (2009) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50301311
Synonyms:
(+/-)3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trifluoromethyl)propanamide | 3,3,3-trifluoro-2-methyl-N-(8-morpholino-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trifluoromethyl)propanamide | CHEMBL567594
Type:
Small organic molecule
Emp. Form.:
C19H22F6N2O2
Mol. Mass.:
424.3806
SMILES:
CC(C(=O)Nc1ccc2CCCC(N3CCOCC3)c2c1)(C(F)(F)F)C(F)(F)F
Structure:
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