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Target
Casein kinase I isoform epsilon
Ligand
BDBM80396
Substrate
n/a
Meas. Tech.
ChEMBL_596750 (CHEMBL1039038)
Kd
300±n/a nM
Citation
 Mott, BT; Tanega, C; Shen, M; Maloney, DJ; Shinn, P; Leister, W; Marugan, JJ; Inglese, J; Austin, CP; Misteli, T; Auld, DS; Thomas, CJ Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett 19:6700-5 (2009) [PubMed]  Article 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM80396
Synonyms:
(1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)-2-propanone | (1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)acetone | (1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | CHEMBL408982 | MLS000518915 | SMR000129335 | cid_1893667
Type:
Small organic molecule
Emp. Form.:
C13H15NO2S
Mol. Mass.:
249.329
SMILES:
CCN1C(Sc2ccc(OC)cc12)=CC(C)=O |w:13.15|
Structure:
Search PDB for entries with ligand similarity: