Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase kinase kinase 19
Ligand
BDBM80396
Substrate
n/a
Meas. Tech.
ChEMBL_596757 (CHEMBL1039045)
Kd
290±n/a nM
Citation
 Mott, BT; Tanega, C; Shen, M; Maloney, DJ; Shinn, P; Leister, W; Marugan, JJ; Inglese, J; Austin, CP; Misteli, T; Auld, DS; Thomas, CJ Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett 19:6700-5 (2009) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase kinase kinase 19
Synonyms:
M3K19_HUMAN | MAP3K19 | RCK | SPS1/STE20-related protein kinase YSK4 | YSK4
Type:
PROTEIN
Mol. Mass.:
150549.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774616
Residue:
1328
Sequence:
MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNKAASKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSWAVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQESASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSFLERSH
  
Inhibitor
Name:
BDBM80396
Synonyms:
(1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)-2-propanone | (1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)acetone | (1E)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one | CHEMBL408982 | MLS000518915 | SMR000129335 | cid_1893667
Type:
Small organic molecule
Emp. Form.:
C13H15NO2S
Mol. Mass.:
249.329
SMILES:
CCN1C(Sc2ccc(OC)cc12)=CC(C)=O |w:13.15|
Structure:
Search PDB for entries with ligand similarity: