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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50303675
Substrate
n/a
Meas. Tech.
ChEMBL_596849 (CHEMBL1045308)
IC50
10172±n/a nM
Citation
 Singh, J; Zeller, W; Zhou, N; Hategan, G; Mishra, RK; Polozov, A; Yu, P; Onua, E; Zhang, J; Ramírez, JL; Sigthorsson, G; Thorsteinnsdottir, M; Kiselyov, AS; Zembower, DE; Andrésson, T; Gurney, ME Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that J Med Chem 53:18-36 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50303675
Synonyms:
2-(1-(2,4-dichlorobenzyl)-1H-benzo[d]imidazol-7-yloxy)-N-(4,5-dichlorothiophen-2-ylsulfonyl)acetamide | CHEMBL565992
Type:
Small organic molecule
Emp. Form.:
C20H13Cl4N3O4S2
Mol. Mass.:
565.277
SMILES:
Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12
Structure:
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