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Target
Histamine H1 receptor
Ligand
BDBM50304528
Substrate
n/a
Meas. Tech.
ChEMBL_604062 (CHEMBL1046851)
Ki
>1000±n/a nM
Citation
 Sander, K; Kottke, T; Tanrikulu, Y; Proschak, E; Weizel, L; Schneider, EH; Seifert, R; Schneider, G; Stark, H 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem 17:7186-96 (2009) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50304528
Synonyms:
CHEMBL593103 | N4-(4-Fluorobenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C16H21FN6
Mol. Mass.:
316.3765
SMILES:
CN1CCN(CC1)c1cc(NCc2ccc(F)cc2)nc(N)n1
Structure:
Search PDB for entries with ligand similarity: