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Target
Histamine H2 receptor
Ligand
BDBM50304528
Substrate
n/a
Meas. Tech.
ChEMBL_604063 (CHEMBL1046852)
Ki
>1000±n/a nM
Citation
 Sander, K; Kottke, T; Tanrikulu, Y; Proschak, E; Weizel, L; Schneider, EH; Seifert, R; Schneider, G; Stark, H 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem 17:7186-96 (2009) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50304528
Synonyms:
CHEMBL593103 | N4-(4-Fluorobenzyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
Type:
Small organic molecule
Emp. Form.:
C16H21FN6
Mol. Mass.:
316.3765
SMILES:
CN1CCN(CC1)c1cc(NCc2ccc(F)cc2)nc(N)n1
Structure:
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