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Target
Hypoxia-inducible factor 1-alpha inhibitor
Ligand
BDBM50304617
Substrate
n/a
Meas. Tech.
ChEMBL_606822 (CHEMBL1068586)
IC50
41400±n/a nM
Citation
 Ko, S; Lee, MK; Shin, D; Park, H Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion. Bioorg Med Chem 17:7769-74 (2009) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha inhibitor
Synonyms:
FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor
Type:
Enzyme
Mol. Mass.:
40278.92
Organism:
Homo sapiens (Human)
Description:
Q9NWT6
Residue:
349
Sequence:
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
  
Inhibitor
Name:
BDBM50304617
Synonyms:
6-((2-methoxyphenoxy)methyl)-3-(quinolin-2-yl)thiazolo[2,3-c][1,2,4]triazole | CHEMBL603864
Type:
Small organic molecule
Emp. Form.:
C21H16N4O2S
Mol. Mass.:
388.442
SMILES:
COc1ccccc1OCc1cn2c(nnc2s1)-c1ccc2ccccc2n1
Structure:
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