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Target
Voltage-dependent calcium channel alpha-2 delta subunit
Ligand
BDBM50304699
Substrate
n/a
Meas. Tech.
ChEMBL_605546 (CHEMBL1067300)
IC50
9280±n/a nM
Citation
 Blakemore, DC; Bryans, JS; Carnell, P; Chessum, NE; Field, MJ; Kinsella, N; Kinsora, JK; Osborne, SA; Williams, SC Synthesis and in vivo evaluation of 3-substituted gababutins. Bioorg Med Chem Lett 20:362-5 (2010) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel alpha-2 delta subunit
Synonyms:
Voltage-dependent calcium channel alpha2delta subunit
Type:
PROTEIN
Mol. Mass.:
123127.66
Organism:
Sus scrofa
Description:
ChEMBL_605546
Residue:
1091
Sequence:
MAAGCLLALTLTLFQSLLIGPSSQEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADILHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIFGIQCVLLWLLSGSRHYQL
  
Inhibitor
Name:
BDBM50304699
Synonyms:
2-(1-(aminomethyl)-3-benzylcyclopentyl)acetic acid | CHEMBL609005
Type:
Small organic molecule
Emp. Form.:
C15H21NO2
Mol. Mass.:
247.3327
SMILES:
NCC1(CC(O)=O)CCC(Cc2ccccc2)C1
Structure:
Search PDB for entries with ligand similarity: