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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50305276
Substrate
n/a
Meas. Tech.
ChEMBL_603319 (CHEMBL1038009)
IC50
1500±n/a nM
Citation
 Ivachtchenko, AV; Frolov, EB; Mitkin, OD; Tkachenko, SE; Okun, IM; Khvat, AV Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. Bioorg Med Chem Lett 20:78-82 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50305276
Synonyms:
8-Fluoro-5-[(Z)-2-(4-methoxyphenyl)-vinyl]-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | CHEMBL592516
Type:
Small organic molecule
Emp. Form.:
C21H21FN2O
Mol. Mass.:
336.4026
SMILES:
COc1ccc(\C=C/n2c3CCN(C)Cc3c3cc(F)ccc23)cc1
Structure:
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