Target
Urokinase-type plasminogen activator
Ligand
BDBM50307283
Substrate
n/a
Meas. Tech.
ChEMBL_610622 (CHEMBL1069636)
Ki
500±n/a nM
Citation
 Wang, SBeck, RBurd, ABlench, TMarlin, FAyele, TBuxton, SDagostin, CMalic, MJoshi, RBarry, JSajad, MCheung, CShaikh, SChahwala, SChander, CBaumgartner, CHolthoff, HPMurray, EBlackney, MGiddings, A Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem 53:1473-82 (2010) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50307283
Synonyms:
(2-Carbamimidoylbenzo[b]thiophen-4-yloxy)phenylacetic Acid Methyl Ester | CHEMBL609911
Type:
Small organic molecule
Emp. Form.:
C18H16N2O3S
Mol. Mass.:
340.396
SMILES:
COC(=O)C(Oc1cccc2sc(cc12)C(N)=N)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: