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Target
Bcl-2-like protein 1
Ligand
BDBM50308110
Substrate
n/a
Meas. Tech.
ChEMBL_610767 (CHEMBL1064402)
Ki
3400±n/a nM
Citation
 Bernardo, PH; Sivaraman, T; Wan, KF; Xu, J; Krishnamoorthy, J; Song, CM; Tian, L; Chin, JS; Lim, DS; Mok, HY; Yu, VC; Tong, JC; Chai, CL Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1. J Med Chem 53:2314-8 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50308110
Synonyms:
(S,Z)-2-(5-((6-(2,3-dimethoxyphenyl)pyridin-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid | CHEMBL605114
Type:
Small organic molecule
Emp. Form.:
C26H22N2O5S2
Mol. Mass.:
506.593
SMILES:
COc1cccc(c1OC)-c1ccc(\C=C2/SC(=S)N([C@@H](Cc3ccccc3)C(O)=O)C2=O)cn1 |r|
Structure:
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