Reaction Details Report a problem with these data
Target
Carbonyl reductase [NADPH] 1
Ligand
BDBM50308750
Substrate
n/a
Meas. Tech.
ChEMBL_607770 (CHEMBL1068741)
IC50
4000±n/a nM
Citation
 Berhe, S; Slupe, A; Luster, C; Charlier, HA; Warner, DL; Zalkow, LH; Burgess, EM; Enwerem, NM; Bakare, O Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase. Bioorg Med Chem 18:134-41 (2010) [PubMed]  Article 
Target
Name:
Carbonyl reductase [NADPH] 1
Synonyms:
CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1
Type:
PROTEIN
Mol. Mass.:
30380.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_607770
Residue:
277
Sequence:
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
  
Inhibitor
Name:
BDBM50308750
Synonyms:
3-(Methyl-N-ethylcarbamate)-6-(N0-methylphenylamino)indazol-4,7-dione | CHEMBL603058
Type:
Small organic molecule
Emp. Form.:
C18H18N4O4
Mol. Mass.:
354.3599
SMILES:
COC(=O)N=CCc1n[nH]c2c(O)c(cc(O)c12)N(C)c1ccccc1 |w:5.5|
Structure:
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