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Target
B1 bradykinin receptor
Ligand
BDBM50309020
Substrate
n/a
Meas. Tech.
ChEMBL_612393 (CHEMBL1066279)
IC50
3500±n/a nM
Citation
 Zischinsky, G; Stragies, R; Schaudt, M; Pfeifer, JR; Gibson, C; Locardi, E; Scharn, D; Richter, U; Kalkhof, H; Dinkel, K; Schnatbaum, K Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles. Bioorg Med Chem Lett 20:1229-32 (2010) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50309020
Synonyms:
CHEMBL605634 | methyl 4'-((1H-benzo[d]imidazol-2-ylamino)methyl)-3,3'-difluorobiphenyl-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H17F2N3O2
Mol. Mass.:
393.3861
SMILES:
COC(=O)c1c(F)cccc1-c1ccc(CNc2nc3ccccc3[nH]2)c(F)c1
Structure:
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