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Target
Phospholipase A-2-activating protein
Ligand
BDBM46049
Substrate
n/a
Meas. Tech.
ChEMBL_610122 (CHEMBL1074487)
IC50
17200±n/a nM
Citation
 Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem 18:573-9 (2010) [PubMed]  Article 
Target
Name:
Phospholipase A-2-activating protein
Synonyms:
PLAA | PLAP | PLAP_HUMAN
Type:
PROTEIN
Mol. Mass.:
87154.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610122
Residue:
795
Sequence:
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL
  
Inhibitor
Name:
BDBM46049
Synonyms:
1-(3,4-dihydroxyphenyl)-2-(2-phenyl-1-imidazolyl)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-(2-phenylimidazol-1-yl)ethanone;hydrochloride | 1-[3,4-bis(oxidanyl)phenyl]-2-(2-phenylimidazol-1-yl)ethanone;hydrochloride | CHEMBL608722 | MLS-0315847.0001 | cid_25067481
Type:
Small organic molecule
Emp. Form.:
C17H14N2O3
Mol. Mass.:
294.3047
SMILES:
Oc1ccc(cc1O)C(=O)Cn1ccnc1-c1ccccc1
Structure:
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