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Target
Phospholipase A-2-activating protein
Ligand
BDBM46041
Substrate
n/a
Meas. Tech.
ChEMBL_610122 (CHEMBL1074487)
IC50
39300±n/a nM
Citation
 Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem 18:573-9 (2010) [PubMed]  Article 
Target
Name:
Phospholipase A-2-activating protein
Synonyms:
PLAA | PLAP | PLAP_HUMAN
Type:
PROTEIN
Mol. Mass.:
87154.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610122
Residue:
795
Sequence:
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL
  
Inhibitor
Name:
BDBM46041
Synonyms:
1-(3,4-dihydroxyphenyl)-2-(isopropylamino)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-(propan-2-ylamino)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-[(propan-2-yl)amino]ethan-1-one, 3 | 1-[3,4-bis(oxidanyl)phenyl]-2-(propan-2-ylamino)ethanone;hydrochloride | CHEMBL598662 | MLS-0315678.0001 | cid_2830496
Type:
Small organic molecule
Emp. Form.:
C11H15NO3
Mol. Mass.:
209.2417
SMILES:
CC(C)NCC(=O)c1ccc(O)c(O)c1
Structure:
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