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Target
Phospholipase A-2-activating protein
Ligand
BDBM46046
Substrate
n/a
Meas. Tech.
ChEMBL_610122 (CHEMBL1074487)
IC50
>100000±n/a nM
Citation
 Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem 18:573-9 (2010) [PubMed]  Article 
Target
Name:
Phospholipase A-2-activating protein
Synonyms:
PLAA | PLAP | PLAP_HUMAN
Type:
PROTEIN
Mol. Mass.:
87154.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_610122
Residue:
795
Sequence:
MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTESEDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGEKVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPGSSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILWKAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSEPAKVSECCRFILNLL
  
Inhibitor
Name:
BDBM46046
Synonyms:
2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(3-methoxy-4-oxidanyl-phenyl)ethanone;hydrochloride | 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1-(4-hydroxy-3-methoxyphenyl)ethanone;hydrochloride | 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-1-(4-hydroxy-3-methoxyphenyl)ethanone;hydrochloride | 2-[(4,6-dimethylpyrimidin-2-yl)thio]-1-(4-hydroxy-3-methoxy-phenyl)ethanone;hydrochloride | CHEMBL596810 | MLS-0315844.0001 | cid_25067475
Type:
Small organic molecule
Emp. Form.:
C15H16N2O3S
Mol. Mass.:
304.364
SMILES:
COc1cc(ccc1O)C(=O)CSc1nc(C)cc(C)n1
Structure:
Search PDB for entries with ligand similarity: