Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50310909
Substrate
n/a
Meas. Tech.
ChEMBL_622830 (CHEMBL1105840)
IC50
99±n/a nM
Citation
 Bedford, ST; Benwell, KR; Brooks, T; Chen, I; Comer, M; Dugdale, S; Haymes, T; Jordan, AM; Kennett, GA; Knight, AR; Klenke, B; LeStrat, L; Merrett, A; Misra, A; Lightowler, S; Padfield, A; Poullennec, K; Reece, M; Simmonite, H; Wong, M; Yule, IA Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. Bioorg Med Chem Lett 19:5945-9 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50310909
Synonyms:
(5-methylthiophen-2-yl)(2-(1-(pyridin-3-yl)ethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone | CHEMBL1079115
Type:
Small organic molecule
Emp. Form.:
C19H16N4OS2
Mol. Mass.:
380.487
SMILES:
CC(Nc1nc(C(=O)c2ccc(C)s2)c2sccc2n1)c1cccnc1
Structure:
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