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Target
Renin
Ligand
BDBM50311801
Substrate
n/a
Meas. Tech.
ChEMBL_619906 (CHEMBL1110296)
IC50
0.68±n/a nM
Citation
 Remen, L; Bezençon, O; Richard-Bildstein, S; Bur, D; Prade, L; Corminboeuf, O; Boss, C; Grisostomi, C; Sifferlen, T; Strickner, P; Hess, P; Delahaye, S; Treiber, A; Weller, T; Binkert, C; Steiner, B; Fischli, W New classes of potent and bioavailable human renin inhibitors. Bioorg Med Chem Lett 19:6762-5 (2009) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50311801
Synonyms:
(1S,5S)-7-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3-oxa-9-azabicyclo[3.3.1]non-6-ene-6-carboxamide | CHEMBL1076443
Type:
Small organic molecule
Emp. Form.:
C33H31Cl3F2N2O3
Mol. Mass.:
647.967
SMILES:
Fc1ccc(F)c(OCCCc2ccc(cc2)C2=C([C@H]3COC[C@H](C2)N3)C(=O)N(Cc2cccc(Cl)c2Cl)C2CC2)c1Cl |r,t:18|
Structure:
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