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Target
Renin
Ligand
BDBM50311809
Substrate
n/a
Meas. Tech.
ChEMBL_619906 (CHEMBL1110296)
IC50
0.74±n/a nM
Citation
 Remen, L; Bezençon, O; Richard-Bildstein, S; Bur, D; Prade, L; Corminboeuf, O; Boss, C; Grisostomi, C; Sifferlen, T; Strickner, P; Hess, P; Delahaye, S; Treiber, A; Weller, T; Binkert, C; Steiner, B; Fischli, W New classes of potent and bioavailable human renin inhibitors. Bioorg Med Chem Lett 19:6762-5 (2009) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50311809
Synonyms:
4-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(3-methoxy-2-methylbenzyl)-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridine-3-carboxamide | CHEMBL1076462
Type:
Small organic molecule
Emp. Form.:
C35H37ClF2N2O3
Mol. Mass.:
607.13
SMILES:
COc1cccc(CN(C2CC2)C(=O)C2=C(C[C@H]3CC[C@H]2N3)c2ccc(CCCOc3c(F)ccc(F)c3Cl)cc2)c1C |r,t:15,TLB:22:15:21:19.18,THB:12:14:21:19.18|
Structure:
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