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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50315652
Substrate
n/a
Meas. Tech.
ChEMBL_623811 (CHEMBL1117094)
IC50
>10000±n/a nM
Citation
 Gopalsamy, A; Shi, M; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R B-Raf kinase inhibitors: hit enrichment through scaffold hopping. Bioorg Med Chem Lett 20:2431-4 (2010) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50315652
Synonyms:
CHEMBL1090143 | N-(3-(6-(pyridin-4-yl)thieno[2,3-d]pyrimidin-4-yl)phenyl)-3-(trifluoromethyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C25H15F3N4OS
Mol. Mass.:
476.473
SMILES:
FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ncnc2sc(cc12)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: