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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50315868
Substrate
n/a
Meas. Tech.
ChEMBL_624964 (CHEMBL1107087)
IC50
7800±n/a nM
Citation
 Luedtke, GR; Schinzel, K; Tan, X; Tester, RW; Nashashibi, I; Xu, YJ; Dugar, S; Levy, DE; Jung, J Amide-based inhibitors of p38alpha MAP kinase. Part 1: discovery of novel N-pyridyl amide lead molecules. Bioorg Med Chem Lett 20:2556-9 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50315868
Synonyms:
(R)-N-(4-fluorobenzyl)-N-(2-(1-phenylethylamino)pyridin-4-yl)-2-naphthamide | CHEMBL1092961
Type:
Small organic molecule
Emp. Form.:
C31H26FN3O
Mol. Mass.:
475.556
SMILES:
C[C@@H](Nc1cc(ccn1)N(Cc1ccc(F)cc1)C(=O)c1ccc2ccccc2c1)c1ccccc1 |r|
Structure:
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