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Target
Aminopeptidase N
Ligand
BDBM50210531
Substrate
n/a
Meas. Tech.
ChEMBL_628651 (CHEMBL1106417)
IC50
3100±n/a nM
Citation
 Li, Q; Fang, H; Wang, X; Xu, W Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Structure-based design, chemistry and activity evaluation. II. Eur J Med Chem 45:1618-26 (2010) [PubMed]  Article 
Target
Name:
Aminopeptidase N
Synonyms:
AMPN_HUMAN | ANPEP | APN | Alanyl aminopeptidase | Aminopeptidase | CD13 | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | PEPN | gp150 | hAPN
Type:
PROTEIN
Mol. Mass.:
109522.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507526
Residue:
967
Sequence:
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
  
Inhibitor
Name:
BDBM50210531
Synonyms:
(S)-N-(1-(2-(Hydroxyamino)-2-oxoethyl)-2,6-dioxpiperidin-3-yl)-3,4,5-trimethoxybenzamide | (S)-N-(1-(2-(hydroxyamino)-2-oxoethyl)-2,6-dioxopiperidin-3-yl)-3,4,5-trimethoxybenzamide | CHEMBL246122
Type:
Small organic molecule
Emp. Form.:
C17H21N3O8
Mol. Mass.:
395.3639
SMILES:
COc1cc(cc(OC)c1OC)C(=O)N[C@H]1CCC(=O)N(CC(=O)NO)C1=O
Structure:
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