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Target
Dynamin-2
Ligand
BDBM50316541
Substrate
n/a
Meas. Tech.
ChEMBL_631206 (CHEMBL1110055)
IC50
16700±n/a nM
Citation
 Hill, TA; Mariana, A; Gordon, CP; Odell, LR; Robertson, MJ; McGeachie, AB; Chau, N; Daniel, JA; Gorgani, NN; Robinson, PJ; McCluskey, A Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J Med Chem 53:4094-102 (2010) [PubMed]  Article 
Target
Name:
Dynamin-2
Synonyms:
DNM2 | DYN2 | DYN2_HUMAN
Type:
PROTEIN
Mol. Mass.:
98071.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_934670
Residue:
870
Sequence:
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
  
Inhibitor
Name:
BDBM50316541
Synonyms:
CHEMBL1096801 | N,N'-(Propane-1,3-diyl)bis(7-hydroxy-2-imino-2H-chromene-3-carboxamide)
Type:
Small organic molecule
Emp. Form.:
C23H20N4O6
Mol. Mass.:
448.4281
SMILES:
Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)cc4oc3=N)c(=N)oc2c1
Structure:
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