Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50316958
Substrate
n/a
Meas. Tech.
ChEMBL_630105 (CHEMBL1110025)
Ki
8.6±n/a nM
Citation
 Yan, Y; Zhou, P; Rotella, DP; Feenstra, R; Kruse, CG; Reinders, JH; van der Neut, M; Lai, M; Zhang, J; Kowal, DM; Carrick, T; Marquis, KL; Pausch, MH; Robichaud, AJ Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia. Bioorg Med Chem Lett 20:2983-6 (2010) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50316958
Synonyms:
7-(4-(2-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)ethyl)piperazin-1-yl)benzo[d]oxazol-2(3H)-one | CHEMBL1087452
Type:
Small organic molecule
Emp. Form.:
C22H24N4O4
Mol. Mass.:
408.4504
SMILES:
O=C1CCc2ccc(OCCN3CCN(CC3)c3cccc4[nH]c(=O)oc34)cc2N1
Structure:
Search PDB for entries with ligand similarity: