Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50317000
Substrate
n/a
Meas. Tech.
ChEMBL_630131 (CHEMBL1113722)
Ki
225±n/a nM
Citation
 Shook, BC; Rassnick, S; Hall, D; Rupert, KC; Heintzelman, GR; Hansen, K; Chakravarty, D; Bullington, JL; Scannevin, RH; Magliaro, B; Westover, L; Carroll, K; Lampron, L; Russell, R; Branum, S; Wells, K; Damon, S; Youells, S; Li, X; Osbourne, M; Demarest, K; Tang, Y; Rhodes, K; Jackson, PF Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorg Med Chem Lett 20:2864-7 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50317000
Synonyms:
2-amino-4-(4-fluorophenyl)-8-((4-methylpiperazin-1-ylamino)methyl)-5H-indeno[1,2-d]pyrimidin-5-one | CHEMBL1087726
Type:
Small organic molecule
Emp. Form.:
C23H23FN6O
Mol. Mass.:
418.4667
SMILES:
CN1CCN(CC1)NCc1ccc2C(=O)c3c(nc(N)nc3-c3ccc(F)cc3)-c2c1
Structure:
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