Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 2
Ligand
BDBM50318898
Substrate
n/a
Meas. Tech.
ChEMBL_633683 (CHEMBL1118308)
EC50
1110±n/a nM
Citation
 Boatman, PD; Schrader, TO; Kasem, M; Johnson, BR; Skinner, PJ; Jung, JK; Xu, J; Cherrier, MC; Webb, PJ; Semple, G; Sage, CR; Knudsen, J; Chen, R; Taggart, AK; Carballo-Jane, E; Richman, JG Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a). Bioorg Med Chem Lett 20:2797-800 (2010) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 2
Synonyms:
G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41868.22
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:
363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
  
Inhibitor
Name:
BDBM50318898
Synonyms:
(4aR,5S,5aR)-3-(1H-tetrazol-5-yl)-5-vinyl-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole | CHEMBL1083683
Type:
Small organic molecule
Emp. Form.:
C10H10N6
Mol. Mass.:
214.2266
SMILES:
C=C[C@H]1[C@H]2Cc3c([nH]nc3-c3nnn[nH]3)[C@@H]12 |r|
Structure:
Search PDB for entries with ligand similarity: