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Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50319080
Substrate
n/a
Meas. Tech.
ChEMBL_635526 (CHEMBL1118109)
IC50
3500±n/a nM
Citation
 Grier, MC; Garrity-Ryan, LK; Bartlett, VJ; Klausner, KA; Donovan, PJ; Dudley, C; Alekshun, MN; Tanaka, SK; Draper, MP; Levy, SB; Kim, OK N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett 20:3380-3 (2010) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
  
Inhibitor
Name:
BDBM50319080
Synonyms:
(E)-N-(4-(6-cyano-1-hydroxy-1H-benzo[d]imidazol-2-yl)phenyl)-3-(6-(methylthio)pyridin-3-yl)acrylamide | CHEMBL1083762
Type:
Small organic molecule
Emp. Form.:
C23H17N5O2S
Mol. Mass.:
427.478
SMILES:
CSc1ccc(\C=C\C(=O)Nc2ccc(cc2)-c2nc3ccc(cc3n2O)C#N)cn1
Structure:
Search PDB for entries with ligand similarity: