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Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50319082
Substrate
n/a
Meas. Tech.
ChEMBL_635526 (CHEMBL1118109)
IC50
31200±n/a nM
Citation
 Grier, MC; Garrity-Ryan, LK; Bartlett, VJ; Klausner, KA; Donovan, PJ; Dudley, C; Alekshun, MN; Tanaka, SK; Draper, MP; Levy, SB; Kim, OK N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett 20:3380-3 (2010) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
  
Inhibitor
Name:
BDBM50319082
Synonyms:
(E)-3-(6-(1H-imidazol-1-yl)pyridin-3-yl)-N-(4-(1-hydroxy-6-nitro-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | CHEMBL1085622
Type:
Small organic molecule
Emp. Form.:
C24H17N7O4
Mol. Mass.:
467.4363
SMILES:
On1c(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(NC(=O)\C=C\c2ccc(nc2)-n2ccnc2)cc1
Structure:
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