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Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50319092
Substrate
n/a
Meas. Tech.
ChEMBL_635525 (CHEMBL1118108)
IC50
7500±n/a nM
Citation
 Grier, MC; Garrity-Ryan, LK; Bartlett, VJ; Klausner, KA; Donovan, PJ; Dudley, C; Alekshun, MN; Tanaka, SK; Draper, MP; Levy, SB; Kim, OK N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett 20:3380-3 (2010) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
  
Inhibitor
Name:
BDBM50319092
Synonyms:
(E)-3-(6-acetylpyridin-3-yl)-N-(4-(1-hydroxy-6-nitro-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide | CHEMBL1084862
Type:
Small organic molecule
Emp. Form.:
C23H17N5O5
Mol. Mass.:
443.4116
SMILES:
CC(=O)c1ccc(C=CC(=O)Nc2ccc(cc2)-c2nc3ccc(cc3n2O)[N+]([O-])=O)cn1 |w:8.8|
Structure:
Search PDB for entries with ligand similarity: