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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50319695
Substrate
n/a
Meas. Tech.
ChEMBL_634759 (CHEMBL1119375)
Ki
26000±n/a nM
Citation
 Matharu, J; Oki, J; Worthen, DR; Smith, QR; Crooks, PA Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett 20:3688-91 (2010) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
L-type amino acid transporter 1 | LAT1_RAT | Lat1 | Mpe16 | Slc7a5 | Ta1
Type:
PROTEIN
Mol. Mass.:
55907.74
Organism:
Rattus norvegicus
Description:
ChEMBL_634760
Residue:
512
Sequence:
MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50319695
Synonyms:
(+/-)-2-Aminobenzo-bicyclo-[2.2.1]heptane-2'-exo-carboxylic acid | CHEMBL1084595
Type:
Small organic molecule
Emp. Form.:
C12H13NO2
Mol. Mass.:
203.2371
SMILES:
NC1(CC2CC1c1ccccc21)C(O)=O |THB:10:11:1.2:4,7:6:1.2:4,0:1:4:6.11|
Structure:
Search PDB for entries with ligand similarity: