Reaction Details Report a problem with these data
Target
Estrogen receptor beta
Ligand
BDBM50251012
Substrate
n/a
Meas. Tech.
ChEMBL_635740 (CHEMBL1120279)
EC50
530±n/a nM
Citation
 Lee, da Y; Kim, do H; Lee, HJ; Lee, Y; Ryu, KH; Jung, BI; Song, YS; Ryu, JH New estrogenic compounds isolated from Broussonetia kazinoki. Bioorg Med Chem Lett 20:3764-7 (2010) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50251012
Synonyms:
CHEMBL465879 | broussonin A
Type:
Small organic molecule
Emp. Form.:
C16H18O3
Mol. Mass.:
258.3123
SMILES:
COc1ccc(CCCc2ccc(O)cc2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: