Reaction Details Report a problem with these data
Target
ATP-dependent 6-phosphofructokinase
Ligand
BDBM50320386
Substrate
n/a
Meas. Tech.
ChEMBL_634086 (CHEMBL1118358)
IC50
170000±n/a nM
Citation
 Ngantchou, I; Nyasse, B; Denier, C; Blonski, C; Hannaert, V; Schneider, B Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei. Bioorg Med Chem Lett 20:3495-8 (2010) [PubMed]  Article 
Target
Name:
ATP-dependent 6-phosphofructokinase
Synonyms:
6-phospho-1-fructokinase | PFKA_TRYBB | pfk
Type:
PROTEIN
Mol. Mass.:
53537.94
Organism:
Trypanosoma brucei
Description:
ChEMBL_1288121
Residue:
487
Sequence:
MAVESRSRVTSKLVKAHRAMLNSVTQEDLKVDRLPGADYPNPSKKYSSRTEFRDKTDYIMYNPRPRDEPSSENPVSVSPLLCELAAARSRIHFNPTETTIGIVTCGGICPGLNDVIRSITLTGINVYNVKRVIGFRFGYWGLSKKGSQTAIELHRGRVTNIHHYGGTILGSSRGPQDPKEMVDTLERLGVNILFTVGGDGTQRGALVISQEAKRRGVDISVFGVPKTIDNDLSFSHRTFGFQTAVEKAVQAIRAAYAEAVSANYGVGVVKLMGRDSGFIAAQAAVASAQANICLVPENPISEQEVMSLLERRFCHSRSCVIIVAEGFGQDWGRGSGGYDASGNKKLIDIGVILTEKVKAFLKANKSRYPDSTVKYIDPSYMIRACPPSANDALFCATLATLAVHEAMAGATGCIIAMRHNNYILVPIKVATSVRRVLDLRGQLWRQVREITVDLGSDVRLARKLEIRRELEAINRNRDRLHEELAKL
  
Inhibitor
Name:
BDBM50320386
Synonyms:
3-O-acetylgreenwayodendrin | CHEMBL1083629
Type:
Small organic molecule
Emp. Form.:
C25H33NO2
Mol. Mass.:
379.535
SMILES:
CC(=O)O[C@H]1CC[C@]2(C)[C@H]3Cc4cc5ccccc5n4[C@]3(C)CC[C@H]2C1(C)C |r|
Structure:
Search PDB for entries with ligand similarity: