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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50323068
Substrate
n/a
Meas. Tech.
ChEMBL_643699 (CHEMBL1212563)
IC50
31400±n/a nM
Citation
 Lv, PC; Sun, J; Luo, Y; Yang, Y; Zhu, HL Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors. Bioorg Med Chem Lett 20:4657-60 (2010) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH)
Type:
Enzyme
Mol. Mass.:
33506.68
Organism:
Escherichia coli
Description:
C3TDZ2
Residue:
317
Sequence:
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
  
Inhibitor
Name:
BDBM50323068
Synonyms:
1-(5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone | CHEMBL1210919
Type:
Small organic molecule
Emp. Form.:
C18H17ClN2O2
Mol. Mass.:
328.793
SMILES:
COc1ccc(cc1)C1=NN(C(C1)c1ccccc1Cl)C(C)=O |t:9|
Structure:
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