Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50012798
Substrate
n/a
Meas. Tech.
ChEMBL_646760 (CHEMBL1216901)
pH
4.4±n/a
IC50
3080±n/a nM
Comments
extracted
Citation
 Choi, S; Connelly, S; Reixach, N; Wilson, IA; Kelly, JW Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. Nat Chem Biol 6:133-9 (2010) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50012798
Synonyms:
(E)-2,6-dimethyl-4-styrylphenol | 2,6-Dimethyl-4-styryl-phenol | 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol | 2,6-dimethyl-4-styrylphenol | CHEMBL55960
Type:
Small organic molecule
Emp. Form.:
C16H16O
Mol. Mass.:
224.2976
SMILES:
Cc1cc(\C=C\c2ccccc2)cc(C)c1O
Structure:
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