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Target
Beta-1 adrenergic receptor
Ligand
BDBM50324829
Substrate
n/a
Meas. Tech.
ChEMBL_651476 (CHEMBL1227593)
Ki
1511±n/a nM
Citation
 Beattie, D; Bradley, M; Brearley, A; Charlton, SJ; Cuenoud, BM; Fairhurst, RA; Gedeck, P; Gosling, M; Janus, D; Jones, D; Lewis, C; McCarthy, C; Oakman, H; Stringer, R; Taylor, RJ; Tuffnell, A A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators. Bioorg Med Chem Lett 20:5302-7 (2010) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50324829
Synonyms:
4-hydroxy-7-((R)-1-hydroxy-2-((1S,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylamino)ethyl)benzo[d]thiazol-2(3H)-one | CHEMBL1221734
Type:
Small organic molecule
Emp. Form.:
C19H26N2O3S
Mol. Mass.:
362.486
SMILES:
CC1(C)[C@@H]2CC[C@]1(C)[C@H](C2)NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12 |r,THB:10:8:4.5:1|
Structure:
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