Reaction Details Report a problem with these data
Target
Cytochrome c oxidase subunit 2
Ligand
BDBM50326829
Substrate
n/a
Meas. Tech.
ChEMBL_662815 (CHEMBL1252215)
IC50
77±n/a nM
Citation
 Zarghi, A; Ghodsi, R Design, synthesis, and biological evaluation of ketoprofen analogs as potent cyclooxygenase-2 inhibitors. Bioorg Med Chem 18:5855-60 (2010) [PubMed]  Article 
Target
Name:
Cytochrome c oxidase subunit 2
Synonyms:
COII | COX2 | COX2_SHEEP | COXII | Cytochrome c oxidase polypeptide II | MT-CO2 | MTCO2
Type:
PROTEIN
Mol. Mass.:
25987.16
Organism:
Ovis aries
Description:
ChEMBL_662815
Residue:
227
Sequence:
MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILIMIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTVRMLISSEDVLPSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML
  
Inhibitor
Name:
BDBM50326829
Synonyms:
6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid | CHEMBL1254785
Type:
Small organic molecule
Emp. Form.:
C24H17NO5S
Mol. Mass.:
431.46
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2cc(ccc2n1)C(=O)c1ccccc1
Structure:
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