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Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Ligand
BDBM50326991
Substrate
n/a
Meas. Tech.
ChEMBL_663438 (CHEMBL1250986)
EC50
17220±n/a nM
Citation
 Melchiorre, M; Del Lungo, M; Guandalini, L; Martini, E; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Sartiani, L; Mugelli, A; Cerbai, E; Romanelli, MN Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J Med Chem 53:6773-7 (2010) [PubMed]  Article 
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Synonyms:
BCNG-2 | Bcng2 | Brain cyclic nucleotide-gated channel 2 | HAC-1 | HCN2_MOUSE | Hac1 | Hcn2 | Hyperpolarization-activated cation channel 1
Type:
PROTEIN
Mol. Mass.:
94741.48
Organism:
Mus musculus
Description:
ChEMBL_663438
Residue:
863
Sequence:
MDARGGGGRPGDSPGTTPAPGPPPPPPPPAPPQPQPPPAPPPNPTTPSHPESADEPGPRARLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRGAASGPSAAEEAGSEEAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWVSINNMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVGPLALGSPRLVRRAPPGPLPPAASPGPPAASPPAAPSSPRAPRTSPYGVPGSPATRVGPALPARRLSRASRPLSASQPSLPHGVPAPSPAASARPASSSTPRLGPAPTARTAAPSPDRRDSASPGAASGLDPLDSARSRLSSNL
  
Inhibitor
Name:
BDBM50326991
Synonyms:
3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)but-2-enyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one | CHEMBL1253993
Type:
Small organic molecule
Emp. Form.:
C27H34N2O5
Mol. Mass.:
466.5693
SMILES:
COc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15|
Structure:
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