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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50327187
Substrate
n/a
Meas. Tech.
ChEMBL_664215 (CHEMBL1261656)
Ki
99±n/a nM
Citation
 Swann, SL; Merta, PJ; Kifle, L; Groebe, D; Sarris, K; Hajduk, PJ; Sun, C Biochemical and biophysical characterization of unique switch pocket inhibitors of p38a. Bioorg Med Chem Lett 20:5787-92 (2010) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50327187
Synonyms:
1-{5-tert-Butyl-2-[3-(1,1,3-trioxo-1lambda*6*-[1,2,5]thiadiazolidin-2-ylmethyl)-phenyl]-2H-pyrazol-3-yl}-3-(4-chloro-phenyl)-urea | 1-{5-tert-Butyl-2-[3-(1,1,3-trioxo-1lambda-6-[1,2,5]thiadiazolidin-2-ylmethyl)-phenyl]-2H-pyrazol-3-yl}-3-(4-chloro-phenyl)-urea | CHEMBL1257218
Type:
Small organic molecule
Emp. Form.:
C23H25ClN6O4S
Mol. Mass.:
517
SMILES:
CC(C)(C)c1cc(NC(=O)Nc2ccc(Cl)cc2)n(n1)-c1cccc(CN2C(O)=CNS2(=O)=O)c1 |c:30|
Structure:
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