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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50327635
Substrate
n/a
Meas. Tech.
ChEMBL_664981 (CHEMBL1259938)
EC50
3200±n/a nM
Citation
 Bridges, TM; Kennedy, JP; Hopkins, CR; Conn, PJ; Lindsley, CW Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett 20:5617-22 (2010) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_HUMAN | CHRM5
Type:
PROTEIN
Mol. Mass.:
60102.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1517990
Residue:
532
Sequence:
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50327635
Synonyms:
1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione | CHEMBL1257151
Type:
Small organic molecule
Emp. Form.:
C17H10F3NO5
Mol. Mass.:
365.2602
SMILES:
FC(F)(F)Oc1ccc2N(Cc3ccc4OCOc4c3)C(=O)C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: