Reaction Details Report a problem with these data
Target
Excitatory amino acid transporter 3
Ligand
BDBM50417031
Substrate
n/a
Meas. Tech.
ChEMBL_664972 (CHEMBL1259929)
IC50
53000±n/a nM
Citation
 Luethi, E; Nguyen, KT; Bürzle, M; Blum, LC; Suzuki, Y; Hediger, M; Reymond, JL Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). J Med Chem 53:7236-50 (2010) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50417031
Synonyms:
CHEMBL2062159 | WAY-855
Type:
Small organic molecule
Emp. Form.:
C9H13NO3
Mol. Mass.:
183.2044
SMILES:
CC(=O)[C@@]1(N)CC[C@@H]2[C@@H]([C@H]12)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: