Reaction Details Report a problem with these data
Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50328246
Substrate
n/a
Meas. Tech.
ChEMBL_665405 (CHEMBL1261134)
EC50
150±n/a nM
Citation
Tang, H; Yan, Y; Feng, Z; de Jesus, RK; Yang, L; Levorse, DA; Owens, KA; Akiyama, TE; Bergeron, R; Castriota, GA; Doebber, TW; Ellsworth, KP; Lassman, ME; Li, C; Wu, MS; Zhang, BB; Chapman, KT; Mills, SG; Berger, JP; Pasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett 20:6088-92 (2010) [PubMed] Article
More Info.:
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_MOUSE | MCD | Mlycd
Type:
PROTEIN
Mol. Mass.:
54752.52
Organism:
Mus musculus
Description:
ChEMBL_665405
Residue:
492
Sequence:
MRGLGPGLRARRLLPLRSPPRPPGPRGRRLCGGLAASAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAEASQRAELLGRLAQGFGVDHGQVAEQSAGVLQLRQQAREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPHVREMNGVLKSMLSEWFSSGFLNLERVTWHSPCEVLQKISECEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISNNIQGIVKECPPTETEERNRIAAAIFYSISLTQQGLQGVELGTFLIKRVVKELQKEFPQLGAFSSLSPIPGFTKWLLGLLNVQGKEHGRNELFTDSECQEISAVTGNPVHESLKGFLSSGEWVKSEKLTQALQGPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVMWRINWMADSSLKGLTSSCGLMVNYRYYLEETGPNSISYLGSKNIKASEQILSLVAQFQNNSKL
Inhibitor
Name:
BDBM50328246
Synonyms:
3-(4-carbamoyl-1-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2-yl)piperidin-4-yl)benzoic acid | CHEMBL1258253
Type:
Small organic molecule
Emp. Form.:
C19H17F6N3O4S
Mol. Mass.:
497.411
SMILES:
NC(=O)C1(CCN(CC1)c1ncc(s1)C(O)(C(F)(F)F)C(F)(F)F)c1cccc(c1)C(O)=O