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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50329774
Substrate
n/a
Meas. Tech.
ChEMBL_674756 (CHEMBL1274064)
Ki
269±n/a nM
Citation
 Kovac, M; Mavel, S; Deuther-Conrad, W; Méheux, N; Glöckner, J; Wenzel, B; Anderluh, M; Brust, P; Guilloteau, D; Emond, P 3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT). Bioorg Med Chem 18:7659-67 (2010) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50329774
Synonyms:
(+)-(2S,3S)-5-(2-fluoroethoxy)-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol | CHEMBL1271850
Type:
Small organic molecule
Emp. Form.:
C23H28FNO2
Mol. Mass.:
369.4723
SMILES:
O[C@H]1Cc2cccc(OCCF)c2C[C@@H]1N1CCC(CC1)c1ccccc1 |r|
Structure:
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