Reaction Details Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50329872
Substrate
n/a
Meas. Tech.
ChEMBL_675735 (CHEMBL1272369)
IC50
4100±n/a nM
Citation
Potter, A; Oldfield, V; Nunns, C; Fromont, C; Ray, S; Northfield, CJ; Bryant, CJ; Scrace, SF; Robinson, D; Matossova, N; Baker, L; Dokurno, P; Surgenor, AE; Davis, B; Richardson, CM; Murray, JB; Moore, JD Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution. Bioorg Med Chem Lett 20:6483-8 (2010) [PubMed] Article
More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50329872
Synonyms:
4-((2-amino-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-imidazole-5-carboxylic acid | 4-[(2-amino-2-oxoethyl)(methyl)carbamoyl]-2-phenyl-1H-imidazole-5-carboxylic acid | CHEMBL1230285
Type:
Small organic molecule
Emp. Form.:
C14H14N4O4
Mol. Mass.:
302.2854
SMILES:
CN(CC(N)=O)C(=O)c1nc([nH]c1C(O)=O)-c1ccccc1